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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL3
All Species:
17.88
Human Site:
T457
Identified Species:
30.26
UniProt:
Q8IVW4
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVW4
NP_001107047.1
592
67514
T457
F
H
P
S
V
R
L
T
E
R
A
K
K
R
R
Chimpanzee
Pan troglodytes
XP_517934
592
67566
T457
F
H
P
S
V
R
L
T
E
R
A
K
K
R
R
Rhesus Macaque
Macaca mulatta
XP_001108660
592
67612
T457
F
H
P
S
V
R
L
T
E
R
A
K
K
R
R
Dog
Lupus familis
XP_850612
456
51739
K345
L
S
T
P
V
L
G
K
E
M
E
R
E
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLF2
595
67720
T459
S
H
P
N
S
R
L
T
E
R
T
K
K
R
R
Rat
Rattus norvegicus
Q9JM01
593
67534
T459
S
H
P
N
S
R
L
T
E
R
T
K
K
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
R458
S
S
T
S
V
G
F
R
A
S
P
R
P
P
S
Chicken
Gallus gallus
P13863
303
34670
T192
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
Frog
Xenopus laevis
P35567
302
34487
G191
P
V
D
V
W
S
I
G
T
I
F
A
E
I
A
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
C239
N
Q
F
F
S
G
V
C
V
P
E
P
Q
E
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
D186
P
R
Y
S
C
P
V
D
I
W
S
I
G
C
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
P476
A
G
P
P
P
L
R
P
N
D
K
M
T
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
T183
L
G
A
R
Q
Y
S
T
P
V
D
V
W
S
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
T183
L
G
S
H
H
Y
S
T
P
V
D
I
W
S
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
67.7
N.A.
80.5
79
N.A.
57.7
25
24.3
31
N.A.
23.4
N.A.
N.A.
30.2
Protein Similarity:
100
99.8
99.6
72.1
N.A.
89.7
87.6
N.A.
68.9
34.9
35.6
43
N.A.
35.1
N.A.
N.A.
44
P-Site Identity:
100
100
100
13.3
N.A.
73.3
73.3
N.A.
13.3
13.3
0
0
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
40
N.A.
80
80
N.A.
20
20
13.3
13.3
N.A.
20
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
22.8
N.A.
23.1
N.A.
N.A.
Protein Similarity:
N.A.
33.9
N.A.
33.9
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
0
0
8
0
29
8
0
8
8
% A
% Cys:
0
0
0
0
8
0
0
8
0
0
0
0
0
8
0
% C
% Asp:
0
8
8
0
0
0
0
8
0
8
15
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
43
0
15
8
15
8
0
% E
% Phe:
22
0
8
8
0
0
8
0
0
8
8
0
0
0
0
% F
% Gly:
0
22
0
0
0
15
15
8
0
0
0
0
8
0
0
% G
% His:
0
36
0
8
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
8
8
0
15
8
0
15
0
8
8
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
8
36
36
15
15
% K
% Leu:
22
0
0
0
0
15
36
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
8
% M
% Asn:
8
0
0
15
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
15
0
43
15
8
8
0
8
15
8
8
8
8
8
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
8
0
8
0
36
8
8
0
36
0
15
0
36
36
% R
% Ser:
22
15
8
36
29
8
15
0
0
8
8
0
0
15
8
% S
% Thr:
0
0
15
0
0
0
0
58
8
0
15
0
8
0
8
% T
% Val:
8
8
0
8
36
0
15
0
8
15
0
8
0
0
15
% V
% Trp:
0
0
0
8
8
0
0
0
0
8
0
0
15
0
0
% W
% Tyr:
0
0
8
0
0
15
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _